The original manuscript has been lost.

原稿已经遗失。

Submit the original manuscript online;

网上提交原稿；

I want to revise my original manuscript.

我想修改原先的手稿。

The original manuscript rests in the museum.

原始手稿在博物馆里。

This has to be part of the original manuscript.

这一定是原稿的一部分。